gondii divides by endodyogeny producing two internally budding daughters per division round. divide asexually by schizogony, producing multiple daughters per division round through a cortical budding process, though at several life-cycle nuclear amplifications stages, are not followed by karyokinesis. and Toxoplasma gondii, a major cause of opportunistic infections. Division modes have been primarily studied in two human pathogenic Apicomplexa, malaria-causing Plasmodium spp. We find that the terminology used to describe the various manifestations of asexual apicomplexan cell division emphasizes either the number of offspring or site of budding, which are not directly comparable features and has led to confusion in the literature. The Apicomplexa display remarkable variation in offspring number, whether karyokinesis follows each S/M-phase or not, and whether daughter cells bud in the cytoplasm or bud from the cortex. The horizon on cell division variants is expanded here by advancing insights on the fascinating cell division modes found in the Apicomplexa, a key group of protozoan parasites. 6Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United StatesĬellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around humans.5School of Biosciences, University of Melbourne, Melbourne, VIC, Australia.4Institute of Parasitology, University of Veterinary Medicine, Vienna, Austria.3Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY, United States.Chan School of Public Health, Harvard University, Boston, MA, United States ![]() ![]() 2Department of Immunology and Infectious Diseases, Harvard T.1Department of Biology, Boston College, Chestnut Hill, MA, United States.Paul 2 Ciara Bauwens 1 Brendan Elsworth 2,5 Klemens Engelberg 1 Daniel K. Keroack 2 Sriveny Dangoudoubiyam 3 † Hanna L.
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